Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224502 | 0.88 | NOTUM (0.59) | NOTUMHRH3F10NPC1RAB9A | |
| SCHEMBL8252670 | 0.87 | NR1H2 (0.43) | NOTUMF10NPC1RAB9AATM | |
| SCHEMBL13163142 | 0.84 | NOTUM (0.58) | NOTUMHRH3F10NPC1RAB9A | |
| SCHEMBL12960968 | 0.82 | NOTUM (0.59) | NOTUMHRH3NPC1RAB9AATM | |
| SCHEMBL10312978 | 0.82 | NOTUM (0.55) | NOTUMHRH3F10NPC1RAB9A | |
| SCHEMBL8198421 | 0.82 | NOTUM (0.55) | NOTUMHRH3F10PRMT5ESR1 | |
| SCHEMBL8253941 | 0.81 | NOTUM (0.54) | NOTUMHRH3F10NPC1RAB9A | |
| SCHEMBL20752768 | 0.79 | NOTUM (0.67) | NOTUMNPC1RAB9ACYP1A2CYP2C9 | |
| SCHEMBL24253498 | 0.79 | DRD2 (0.51) | HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10205360 | 0.78 | NOTUM (0.46) | NOTUMHRH3F10MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |