Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.72 |
| ▸ | FLT1 | P17948 | 11/20 | 0.72 |
| ▸ | FLT4 | P35916 | 7/20 | 0.72 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.72 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.72 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.72 |
| ▸ | EGFR | P00533 | 6/20 | 0.63 |
| ▸ | RET | P07949 | 5/20 | 0.59 |
| ▸ | KIF5B | P33176 | 3/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451648 | 0.93 | KDR (0.70) | KDRFGFR1FLT1FLT4FGFR2 | |
| Hydrochloric Acid SCHEMBL7456416 | 0.92 | KDR (0.69) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL7455061 | 0.87 | FLT1 (0.72) | KDRFGFR1FLT1FLT4FGFR2 | |
| Hydrochloric Acid SCHEMBL7712373 | 0.86 | FLT1 (0.71) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL7455262 | 0.85 | KDR (0.74) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL7209641 | 0.84 | KDR (1.00) | KDRFGFR1FLT1FLT4FGFR2 | |
| Hydrochloric Acid SCHEMBL7458122 | 0.84 | KDR (0.72) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL7452251 | 0.84 | KDR (0.76) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL5958891 | 0.84 | KDR (0.84) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL7451363 | 0.84 | KDR (0.77) | KDRFGFR1FLT1FLT4FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071921-A | Chemical compounds | ZENECA LIMITED (GB) | 2000-06-06 | — | — | US | disclosed |