Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199848 | 0.89 | NPC1 (0.44) | NPC1RAB9AGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL5015072 | 0.87 | NPC1 (0.54) | NPC1RAB9AGAALMNATP53 | |
| SCHEMBL7328664 | 0.82 | HPGD (0.45) | NPC1RAB9AGAALMNATP53 | |
| SCHEMBL30262248 | 0.81 | NPC1 (0.48) | NPC1RAB9AGAALMNATP53 | |
| SCHEMBL6236607 | 0.79 | GAA (0.51) | NPC1RAB9AGAAHSP90AA1MAPK1 | |
| SCHEMBL12330710 | 0.79 | TDP1 (0.48) | GAATP53NPSR1SMN1; SMN2NQO2 | |
| SCHEMBL13903547 | 0.78 | GAA (0.45) | NPC1RAB9AGAAKDM4A | |
| SCHEMBL7335575 | 0.77 | POLB (0.46) | GAALMNATP53PKMXBP1 | |
| SCHEMBL15171404 | 0.77 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2KDM4AALDH1A1 | |
| SCHEMBL31705342 | 0.74 | KDM4A (0.44) | NPC1RAB9AGAAKDM4ANQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672678-B1 | Azapeptide derivative | FUJIREBIO KK (JP) | 2000-10-25 | — | — | EP | disclosed |
| US-5965538-A | FOR TREATING NERVOUS INFLAMMATION OF RESPIRATORY SYSTEMS, ASTHMA, BRONCHOSPASM | FUJIREBIO INC. (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5837687-A | BRONCHODILATORS, ANTIHISTAMINES AND ANTIINFLAMMATORY AGENTS; ASTHMA; ANTAGONIST OF NEUROKININ RECEPTORS | FUJIREBIO INC. (JP) | 1998-11-17 | — | — | US | disclosed |
| EP-0672678-A1 | Azapeptide derivative | FUJIREBIO Inc. (JP) | 1995-09-20 | — | — | EP | disclosed |