Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203893 | 0.89 | NPC1 (0.44) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL15171404 | 0.85 | NPC1 (0.52) | NPC1RAB9ACCR2KDM4EALDH1A1 | |
| SCHEMBL7328664 | 0.82 | HPGD (0.45) | NPC1RAB9AKDM4EALDH1A1GAA | |
| SCHEMBL6236607 | 0.79 | GAA (0.51) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7335575 | 0.77 | POLB (0.46) | KDM4EALDH1A1GAAMAPTPOLB | |
| SCHEMBL13903547 | 0.75 | GAA (0.45) | NPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL5015072 | 0.75 | NPC1 (0.54) | NPC1RAB9AALDH1A1SMN1; SMN2P2RX7 | |
| SCHEMBL7975698 | 0.75 | SMN1; SMN2 (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6762260 | 0.74 | MAPT (0.39) | KDM4EALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL18692366 | 0.74 | APLNR (0.54) | ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672678-B1 | Azapeptide derivative | FUJIREBIO KK (JP) | 2000-10-25 | — | — | EP | disclosed |
| US-5965538-A | FOR TREATING NERVOUS INFLAMMATION OF RESPIRATORY SYSTEMS, ASTHMA, BRONCHOSPASM | FUJIREBIO INC. (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5837687-A | BRONCHODILATORS, ANTIHISTAMINES AND ANTIINFLAMMATORY AGENTS; ASTHMA; ANTAGONIST OF NEUROKININ RECEPTORS | FUJIREBIO INC. (JP) | 1998-11-17 | — | — | US | disclosed |
| EP-0672678-A1 | Azapeptide derivative | FUJIREBIO Inc. (JP) | 1995-09-20 | — | — | EP | disclosed |