Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.74 |
| ▸ | DRD1 | P21728 | 9/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | DRD5 | P21918 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196479 | 0.91 | DRD2 (0.69) | DRD2DRD1ALDH1A1DRD3DRD5 | |
| SCHEMBL29623704 | 0.91 | DRD2 (0.90) | DRD2DRD1ALDH1A1DRD3DRD5 | |
| SCHEMBL8203911 | 0.89 | DRD2 (0.75) | DRD2DRD1ALDH1A1DRD3DRD5 | |
| SCHEMBL8204038 | 0.89 | DRD2 (0.69) | DRD2DRD1ALDH1A1DRD3DRD5 | |
| SCHEMBL8204496 | 0.85 | DRD2 (0.77) | DRD2DRD1ALDH1A1DRD3DRD5 | |
| SCHEMBL8203868 | 0.84 | DRD2 (0.76) | DRD2DRD1ALDH1A1DRD3DRD5 | |
| SCHEMBL8202569 | 0.84 | DRD1 (0.64) | DRD2DRD1ALDH1A1DRD3DRD5 | |
| SCHEMBL9050759 | 0.82 | DRD2 (0.62) | DRD2DRD1ALDH1A1DRD3MEN1 | |
| SCHEMBL8204077 | 0.79 | CHRM1 (0.64) | DRD2DRD1ALDH1A1DRD3DRD5 | |
| SCHEMBL8202579 | 0.79 | DRD2 (0.61) | DRD2DRD1ALDH1A1DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103715-A | COMPOUNDS THAT BIND TO THE DOPAMINE D4 RECEPTOR AND THEIR USE AS ANXIOLYTIC AGENTS, TREATMENT FOR SCHIZOPHRENIA, AND DRUG SCREENING; SIDE EFFECT REDUCTIOON | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-15 | — | — | US | disclosed |
| EP-0736024-A1 | N-HETEROBICYCLYL-PIPERAZINYL OR-PIPERADINYL TRICYCLIC DERIVATIVES USEFUL AS DOPAMINE RECEPTOR LIGANDS | Allelix Biopharmaceuticals Inc. (CA) | 1996-10-09 | — | — | EP | disclosed |
| US-5538965-A | TREATMENT OF PSYCHOLOGICAL DISORDERS SUCH AS SCHIZOPHRENIA AND ANXIETY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1996-07-23 | — | — | US | disclosed |
| WO-1995017400-A1 | N-HETEROBICYCLYL-PIPERAZINYL OR-PIPERADINYL TRICYCLIC DERIVATIVES USEFUL AS DOPAMINE RECEPTOR LIGANDS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1995-06-29 | — | — | WO | disclosed |