SCHEMBL8204331

SCHEMBL8204331

COc1cccc2cc(C(=O)O)c(OCc3ccccc3)cc12

nearest known ligand 0.72

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.72
KDM4E B2RXH2 2/20 0.72
ALDH1A1 P00352 2/20 0.72
HSD17B10 Q99714 1/20 0.72
CTSV O60911 2/20 0.56
CTSL P07711 2/20 0.56
MRGPRX4 Q96LA9 3/20 0.55
RXRA P19793 1/20 0.52
PTGER1 P34995 2/20 0.50
FOLH1 Q04609 1/20 0.50
SRD5A2 P31213 3/20 0.49
SRD5A1 P18405 2/20 0.49
MEN1 O00255 1/20 0.49
POLB P06746 1/20 0.49
KMT2A Q03164 1/20 0.49
ATM Q13315 1/20 0.48
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8207549 0.95 ALDH1A1 (0.72) HPGDKDM4EALDH1A1HSD17B10CTSV
SCHEMBL8202357 0.90 KDM4E (0.58) HPGDKDM4EALDH1A1HSD17B10CTSV
SCHEMBL8203011 0.85 ALDH1A1 (0.58) HPGDKDM4EALDH1A1HSD17B10CTSV
SCHEMBL8117517 0.85 ALDH1A1 (0.54) HPGDKDM4EALDH1A1HSD17B10CTSV
SCHEMBL551105 0.85 ALDH1A1 (1.00) HPGDKDM4EALDH1A1HSD17B10POLB
SCHEMBL29353299 0.85 ALDH1A1 (1.00) HPGDKDM4EALDH1A1HSD17B10POLB
SCHEMBL7273836 0.82 FOLH1 (0.61) HPGDKDM4EALDH1A1CTSVCTSL
SCHEMBL10390521 0.82 GRIN2D (0.57) HPGDKDM4EALDH1A1HSD17B10CTSV
SCHEMBL10390734 0.81 MRGPRX4 (0.50) HPGDKDM4EALDH1A1HSD17B10CTSV
SCHEMBL1681414 0.81 KMT2A (0.53) HPGDKDM4EALDH1A1HSD17B10MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136969-A PROTEIN KINASE INHIBITORS; 4-HYDROXYBENZOIC ACID 3-(4-(4-FLUOROBENZOYLOXY)-BENZOYLAMINO)-AZEPAN-4-YL ESTER HOFFMANN-LA ROCHE INC. (US) 2000-10-24 US disclosed
US-5907038-A PROTEIN KINASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 1999-05-25 US disclosed
EP-0836592-A1 AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES F. HOFFMANN-LA ROCHE AG (CH) 1998-04-22 EP disclosed
WO-1997002249-A1 NOVEL AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES F. HOFFMANN-LA ROCHE AG (CH) 1997-01-23 WO disclosed