Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL27760268 | 0.75 | — | — | |
| SCHEMBL3924300 | 0.73 | MAOA (0.32) | MAOAMAOBMAPT | |
| SCHEMBL28596155 | 0.71 | MAOA (0.34) | MAOAMAOBNISCHCYP19A1MEN1 | |
| SCHEMBL7347250 | 0.71 | KDM1A (0.35) | MAOAMAOBNISCHATM | |
| SCHEMBL449446 | 0.71 | MAOA (0.34) | MAOAMAOBNISCHCYP19A1MEN1 | |
| SCHEMBL17185573 | 0.71 | MAOA (0.34) | MAOAMAOBNISCHCYP19A1MEN1 | |
| SCHEMBL7022979 | 0.67 | CYP19A1 (0.32) | MAOAMAOBCYP19A1ATM | |
| SCHEMBL2481773 | 0.67 | MAOA (0.35) | MAOAMAOBATM | |
| SCHEMBL7534538 | 0.67 | MAOA (0.31) | MAOAMAOBMEN1LMNAMAPT | |
| SCHEMBL7374209 | 0.66 | MAOA (0.31) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991620-A1 | PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 2000-04-12 | — | — | EP | claimed |
| WO-1998057933-A1 | PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-12-23 | — | — | WO | claimed |