Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | FAAH | O00519 | 2/20 | 0.56 |
| ▸ | LHCGR | P22888 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080530 | 0.91 | ALDH1A1 (0.63) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| SCHEMBL1890946 | 0.88 | ALDH1A1 (0.83) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| Tert-Butyl Formate SCHEMBL28865514 | 0.87 | ALDH1A1 (0.56) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| SCHEMBL5115600 | 0.85 | ALDH1A1 (0.97) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| SCHEMBL8395644 | 0.85 | ALDH1A1 (0.90) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| SCHEMBL8393776 | 0.83 | ALDH1A1 (1.00) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| SCHEMBL21618461 | 0.83 | ALDH1A1 (1.00) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| SCHEMBL1532563 | 0.83 | ALDH1A1 (1.00) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| Bicarbonate SCHEMBL15226094 | 0.82 | ALDH1A1 (0.97) | ALDH1A1RAB9AFAAHLHCGREPHX1 | |
| SCHEMBL5899171 | 0.82 | ALDH1A1 (0.73) | ALDH1A1RAB9AFAAHLHCGREPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |