Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTR | Q99707 | 1/20 | 0.54 |
| ▸ | SCN1A | P35498 | 13/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 13/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 13/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204791 | 1.00 | MTR (0.54) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL8202592 | 0.81 | MTR (0.64) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL7237147 | 0.80 | MTR (0.69) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL7237153 | 0.80 | MTR (0.69) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL7238535 | 0.80 | MTR (0.69) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL8483204 | 0.78 | MTR (0.45) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL8191068 | 0.75 | MTR (0.48) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL8191064 | 0.75 | MTR (0.48) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL7244168 | 0.75 | MTR (0.58) | MTRSCN1ASCN5ASCN9ANPY1R | |
| SCHEMBL6191353 | 0.73 | MTR (0.66) | MTRSCN1ASCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034098-A | ATHEROSCLEROSIS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-03-07 | — | — | US | claimed |
| EP-0643057-A1 | Inhibitors of microsomal triglyceride transfer protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-03-15 | — | — | EP | claimed |
| US-6066650-A | USEFUL FOR LOWERING SERUM LIPIDS AND TREATING ATHEROSCLEROSIS AND RELATED DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-23 | — | — | US | disclosed |
| US-6034098-A | ATHEROSCLEROSIS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0643057-A1 | Inhibitors of microsomal triglyceride transfer protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-03-15 | — | — | EP | disclosed |