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Sugi Predict / Targets / MTR

MTR

Methionine synthase · Q99707 · MTR on Sugi Atlas →

1,697 patent compounds predicted against MTR, 1,120 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL6187526 SCHEMBL6187526 0.58 2/20
SCHEMBL6191113 SCHEMBL6191113 0.51 2/20
SCHEMBL6601007 SCHEMBL6601007 0.51 2/20
SCHEMBL6187393 SCHEMBL6187393 0.50 2/20
SCHEMBL6189174 SCHEMBL6189174 0.49 2/20
Lomitapide Lomitapide (SCHEMBL304604) 1.00 1/20
SCHEMBL4202150 SCHEMBL4202150 1.00 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL3150610) 0.98 1/20
Lomitapide Lomitapide (SCHEMBL2731380) 0.93 1/20
SCHEMBL6600443 SCHEMBL6600443 0.86 1/20
SCHEMBL6188141 SCHEMBL6188141 0.85 1/20
SCHEMBL6603726 SCHEMBL6603726 0.85 1/20
SCHEMBL6186640 SCHEMBL6186640 0.84 1/20
SCHEMBL1395278 SCHEMBL1395278 0.80 1/20
SCHEMBL6600438 SCHEMBL6600438 0.79 1/20
SCHEMBL6601117 SCHEMBL6601117 0.79 1/20
SCHEMBL6192946 SCHEMBL6192946 0.78 1/20
SCHEMBL6603096 SCHEMBL6603096 0.78 1/20
SCHEMBL6605348 SCHEMBL6605348 0.78 1/20
SCHEMBL474074 SCHEMBL474074 0.78 1/20

Clinical trials — most relevant to MTR by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis PHASE4COMPLETED
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation PHASE2UNKNOWN
Study of SGN1 in Patients With Advanced Solid Tumor PHASE1/PHASE2RECRUITING
Study of SGN1 Administered Via Intratumoral Injection in Patients With Advanced Solid Tumor PHASE1/PHASE2RECRUITING
L-carnitine Supplementation in Rheumatoid Arthritis Patients PHASE2RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Methionine-Restriction Diet (MRD) in Obese Adults With Metabolic Syndrome PHASE2COMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD nanNOT_YET_RECRUITING
Dietary Effects of Sulfur Amino Acids nanCOMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism nanCOMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children nanWITHDRAWN
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma nanCOMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Dietary Interventions During Living Kidney Donations nanRECRUITING
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
Diabetic Cardiomyopathy and Heart Failure nanWITHDRAWN
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels nanCOMPLETED
Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma nanUNKNOWN
Methionine and Cysteine Restriction in Humans nanCOMPLETED
Study of Homocysteine Metabolism in Homocystinuria nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Early Nutritional Intervention in Patients With Autism Spectrum Disorders nanCOMPLETED
Environmental Pollutants in COPD and Lung Cancer nanRECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MTR binder may also engage these)

ProteinNameSimilarity
A6H5Y3 — 1.000 A6H5Y3 →
A8XY95 — 1.000 A8XY95 →
Q4JIJ3 — 1.000 Q4JIJ3 →
Q9Z2Q4 — 1.000 Q9Z2Q4 →
Q09582 — 1.000 Q09582 →
Q54P92 — 0.999 Q54P92 →
Q5E814 — 0.999 Q5E814 →
Q9AJQ8 — 0.998 Q9AJQ8 →
Q87L95 — 0.997 Q87L95 →
B1JLQ4 — 0.996 B1JLQ4 →
Q66EZ3 — 0.996 Q66EZ3 →
B2K3F7 — 0.996 B2K3F7 →
Q8KBL4 — 0.996 Q8KBL4 →
A4YKQ8 — 0.996 A4YKQ8 →
B9JV07 — 0.996 B9JV07 →
Q1CN19 — 0.995 Q1CN19 →
A9R0S6 — 0.995 A9R0S6 →
Q9KUW9 — 0.995 Q9KUW9 →
Q9AMC5 — 0.995 Q9AMC5 →
Q3M7G3 — 0.995 Q3M7G3 →
Q5NH64 — 0.995 Q5NH64 →
A6TEB4 — 0.995 A6TEB4 →
Q2K333 — 0.995 Q2K333 →
B7GMF3 — 0.995 B7GMF3 →
P48069 — 0.995 P48069 →
C0MH17 — 0.995 C0MH17 →
A5ETI5 — 0.995 A5ETI5 →
P48073 — 0.994 P48073 →
Q1QQI9 — 0.994 Q1QQI9 →
P47639 — 0.994 P47639 →