Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.53 |
| ▸ | GLS2 | Q9UI32 | 3/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.49 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | CTSH | P09668 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5945552 | 0.98 | CTSK (0.52) | CTSKGLS2CTSLCTSBCSNK1E | |
| SCHEMBL27549298 | 0.98 | CTSK (0.52) | CTSKGLS2CTSLCTSBCSNK1E | |
| SCHEMBL11308906 | 0.97 | CTSK (0.51) | CTSKGLS2CTSLCTSBCSNK1E | |
| SCHEMBL1837041 | 0.89 | CTSK (0.54) | CTSKCTSLCTSBCSNK1EDAGLA | |
| SCHEMBL2289952 | 0.89 | CTSK (0.56) | CTSKCTSLCTSBCTSHMMP12 | |
| SCHEMBL12378816 | 0.89 | CTSK (0.56) | CTSKCTSLCTSBCTSHMMP12 | |
| SCHEMBL1837115 | 0.88 | CTSK (0.53) | CTSKCTSLCTSBCSNK1EDAGLA | |
| SCHEMBL1841343 | 0.88 | CTSK (0.53) | CTSKCTSLCTSBCSNK1EDAGLA | |
| SCHEMBL1839268 | 0.88 | CTSK (0.53) | CTSKCTSLCTSBCSNK1EDAGLA | |
| SCHEMBL29127650 | 0.86 | GLS2 (0.52) | GLS2ALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |