SCHEMBL8204899

SCHEMBL8204899

[C]#Cc1c(O)ccc2ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN22 Q9Y2R2 1/20 0.54
POLB P06746 1/20 0.50
HSD17B10 Q99714 3/20 0.48
CYP1A2 P05177 2/20 0.48
USP2 O75604 1/20 0.48
PAK1 Q13153 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
MAPT P10636 4/20 0.46
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 3/20 0.46
GAA P10253 3/20 0.46
TAAR1 Q96RJ0 1/20 0.46
ERN1 O75460 1/20 0.46
TDP1 Q9NUW8 3/20 0.44
CYP2A6 P11509 1/20 0.44
TSHR P16473 1/20 0.44
IDO1 P14902 1/20 0.42
GLA P06280 1/20 0.42
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3244528 0.79 PTPN22 (0.54) PTPN22POLBHSD17B10CYP1A2USP2
SCHEMBL20529660 0.79 PTPN22 (0.54) PTPN22POLBHSD17B10CYP1A2USP2
SCHEMBL30393017 0.79 PTPN22 (0.54) PTPN22POLBHSD17B10CYP1A2USP2
SCHEMBL1855575 0.79 ESR1 (0.54) PTPN22POLBHSD17B10CYP1A2USP2
Benzene SCHEMBL21836124 0.78 PTPN22 (0.52) PTPN22POLBHSD17B10CYP1A2USP2
SCHEMBL28497134 0.76 PTPN22 (0.50) PTPN22POLBHSD17B10CYP1A2USP2
SCHEMBL28624944 0.75 PTPN22 (0.48) PTPN22POLBHSD17B10CYP1A2USP2
SCHEMBL28797628 0.73 PTPN22 (0.47) PTPN22POLBHSD17B10CYP1A2USP2
SCHEMBL1611801 0.73 ALDH1A1 (0.44) POLBHSD17B10CYP1A2CYP2C19MAPT
SCHEMBL20529698 0.72 PTPN22 (0.46) PTPN22POLBHSD17B10CYP1A2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6096144-A TREATING WITH ACIDIC OR ALKALINE SOLUTION OF CONJUGATED UNSATURATED COMPOUND WITH AT LEAST 5 BONDS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2000-08-01 US disclosed
US-5858571-A TREATING A PULVERIZED HYDROGEN ABSORBING ALLOY WITH A SOLUTION COMPRISING A CONJUGATED UNSATURATED COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-01-12 US disclosed