Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.36 |
| ▸ | PDE4A | P27815 | 13/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.34 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.34 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192375 | 0.85 | PDE4A (0.39) | PDE10APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8175915 | 0.83 | PDE4A (0.54) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8187093 | 0.82 | PDE4A (0.37) | PDE10APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8177267 | 0.82 | PDE4A (0.37) | PDE10APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8187111 | 0.81 | PDE4A (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8191475 | 0.79 | PDE10A (0.42) | PDE10AKCNN3KCNN1KCNN2 | |
| SCHEMBL12126898 | 0.79 | PDE10A (0.42) | PDE10APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8185998 | 0.78 | PDE10A (0.41) | PDE10AKCNN3KCNN1KCNN2 | |
| SCHEMBL8185583 | 0.72 | PDE10A (0.36) | PDE10AKCNN3KCNN1KCNN2 | |
| SCHEMBL22978862 | 0.71 | PDE10A (0.40) | PDE10AKCNN3KCNN1KCNN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021447-A1 | PYRROLOPYRAZOLOPYRIMIDINE COMPOUND AND MEDICINE COMPRISING THE SAME | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998033799-A1 | PYRROLOPYRAZOLOPYRIMIDINE COMPOUND AND MEDICINE COMPRISING THE SAME | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1998-08-06 | — | — | WO | disclosed |