Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142215 | 1.00 | KMT2A (0.39) | KMT2AL3MBTL1SMPD1MAPK1NR1H4 | |
| SCHEMBL8142168 | 0.92 | NR1H4 (0.41) | SMPD1NR1H4HDAC3HDAC2EPHX2 | |
| SCHEMBL8128937 | 0.92 | KMT2A (0.40) | KMT2AL3MBTL1SMPD1MAPK1NR1H4 | |
| SCHEMBL8129705 | 0.92 | L3MBTL1 (0.40) | KMT2AL3MBTL1SMPD1MAPK1NR1H4 | |
| SCHEMBL8149905 | 0.91 | NR1H4 (0.35) | L3MBTL1SMPD1NR1H4HDAC3HDAC2 | |
| SCHEMBL8148216 | 0.91 | LPAR1 (0.41) | MAPK1HDAC3HDAC2MAPT | |
| SCHEMBL8130312 | 0.91 | KMT2A (0.39) | KMT2AL3MBTL1SMPD1MAPK1NR1H4 | |
| SCHEMBL8148025 | 0.90 | L3MBTL1 (0.38) | KMT2AL3MBTL1SMPD1MAPK1NR1H4 | |
| SCHEMBL8134869 | 0.90 | L3MBTL1 (0.34) | KMT2AL3MBTL1SMPD1NR1H4HDAC3 | |
| SCHEMBL8134646 | 0.90 | LPAR1 (0.40) | MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040339-A | TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA OR ARTERIOSCLEROSIS IN A MAMMAL | SANKYO COMPANY, LIMITED (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5880147-A | Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use | SANKYO COMPANY, LIMITED (JP) | 1999-03-09 | — | — | US | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |