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Mannose 6-Phosphate

Mannose 6-Phosphate

SCHEMBL8205373

CC(=O)C(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(=O)(O)O

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MPI P34949 1/20 0.55
▸ PGD P52209 3/20 0.41
▸ PGK1 P00558 1/20 0.36
▸ PGK2 P07205 1/20 0.36
▸ LPAR1 Q92633 3/20 0.33
▸ LPAR6 P43657 1/20 0.33
▸ LPAR4 Q99677 1/20 0.33
▸ LPAR5 Q9H1C0 1/20 0.33
▸ LPAR2 Q9HBW0 1/20 0.33
▸ LPAR3 Q9UBY5 1/20 0.33
▸ ENPP2 Q13822 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6151201 0.88 MPI (0.34) MPI
SCHEMBL873894 0.88 MPI (0.34) MPI
SCHEMBL8205372 0.86 MPI (0.39) MPI
Mannose 6-Phosphate SCHEMBL9736768 0.85 MPI (0.75) MPIPGDPGK1PGK2LPAR5
Mannose 6-Phosphate SCHEMBL1874195 0.85 MPI (0.75) MPIPGDPGK1PGK2LPAR5
Mannose 6-Phosphate SCHEMBL9738212 0.85 MPI (0.75) MPIPGDPGK1PGK2LPAR5
Mannose 6-Phosphate SCHEMBL9739836 0.85 MPI (0.75) MPIPGDPGK1PGK2LPAR5
Mannose 6-Phosphate SCHEMBL20798006 0.85 MPI (0.75) MPIPGDPGK1PGK2LPAR5
Mannose 6-Phosphate SCHEMBL2319337 0.85 MPI (0.75) MPIPGDPGK1PGK2LPAR5
Mannose 6-Phosphate SCHEMBL6599 0.85 MPI (0.75) MPIPGDPGK1PGK2LPAR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6011001-A Method of protein therapy by orally administering crosslinked protein crystals VERTEX PHARMACEUTICALS, INC. (US) 2000-01-04 — — US disclosed
US-6004768-A Biosensors, extracorporeal devices and methods for detecting substances using crosslinked protein crystals VERTEX PHARMACEUTICALS, INC. (US) 1999-12-21 — — US disclosed
US-5976529-A Methods of enzyme therapy by orally administering crosslinked enzyme crystals VERTEX PHARMACEUTICALS, INC. (US) 1999-11-02 — — US disclosed
US-5849296-A Crosslinked protein crystals VERTEX PHARMACEUTICALS, INC. (US) 1998-12-15 — — US disclosed
US-5618710-A RESISTANCE TO EXOGENOUS PROTEOLYSIS VERTEX PHARMACEUTICALS, INC. (US) 1997-04-08 — — US disclosed