Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.73 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | IDE | P14735 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205507 | 1.00 | CTNNB1 (0.73) | CTNNB1TCF7L2MEN1KMT2ACRHBP | |
| SCHEMBL8187806 | 0.89 | PDE4B (0.61) | CTNNB1TCF7L2MEN1KMT2ACRHBP | |
| SCHEMBL8187803 | 0.89 | PDE4B (0.61) | CTNNB1TCF7L2MEN1KMT2ACRHBP | |
| SCHEMBL8205466 | 0.87 | PDE4B (0.62) | CTNNB1TCF7L2MEN1KMT2AALDH1A1 | |
| SCHEMBL19999128 | 0.87 | PDE4B (0.62) | CTNNB1TCF7L2MEN1KMT2AALDH1A1 | |
| SCHEMBL8205465 | 0.87 | PDE4B (0.62) | CTNNB1TCF7L2MEN1KMT2AALDH1A1 | |
| SCHEMBL18095868 | 0.85 | CTNNB1 (1.00) | CTNNB1TCF7L2MEN1KMT2AALDH1A1 | |
| SCHEMBL12008481 | 0.85 | CTNNB1 (1.00) | CTNNB1TCF7L2MEN1KMT2AALDH1A1 | |
| SCHEMBL18102970 | 0.85 | CTNNB1 (1.00) | CTNNB1TCF7L2MEN1KMT2AALDH1A1 | |
| SCHEMBL12008548 | 0.83 | CTNNB1 (0.89) | CTNNB1TCF7L2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000032598-A9 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC (US) | 2000-11-30 | — | — | WO | claimed |
| WO-2000032598-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC. (US) | 2000-06-08 | — | — | WO | disclosed |