Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.62 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.60 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 11/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.55 |
| ▸ | NSD2 | O96028 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 5/20 | 0.53 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | IDE | P14735 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205466 | 1.00 | PDE4B (0.62) | PDE4BCTNNB1TCF7L2MEN1KMT2A | |
| SCHEMBL19999128 | 1.00 | PDE4B (0.62) | PDE4BCTNNB1TCF7L2MEN1KMT2A | |
| SCHEMBL19999129 | 0.92 | CTNNB1 (0.64) | PDE4BCTNNB1TCF7L2MEN1KMT2A | |
| SCHEMBL19999075 | 0.88 | CTNNB1 (0.59) | CTNNB1TCF7L2MEN1KMT2ANSD2 | |
| SCHEMBL19999126 | 0.88 | CTNNB1 (0.57) | PDE4BCTNNB1TCF7L2MEN1KMT2A | |
| SCHEMBL18102989 | 0.88 | CTNNB1 (0.65) | CTNNB1TCF7L2MEN1KMT2APOLB | |
| SCHEMBL18095863 | 0.88 | CTNNB1 (0.65) | CTNNB1TCF7L2MEN1KMT2APOLB | |
| SCHEMBL18095861 | 0.88 | CTNNB1 (0.65) | CTNNB1TCF7L2MEN1KMT2APOLB | |
| SCHEMBL8205510 | 0.87 | CTNNB1 (0.73) | PDE4BCTNNB1TCF7L2MEN1KMT2A | |
| SCHEMBL8205507 | 0.87 | CTNNB1 (0.73) | PDE4BCTNNB1TCF7L2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000032598-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC. (US) | 2000-06-08 | — | — | WO | claimed |
| WO-2000032598-A9 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC (US) | 2000-11-30 | — | — | WO | disclosed |