Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.34 |
| ▸ | MPO | P05164 | 4/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13122355 | 0.81 | AR (0.43) | ARGPR84LMNASLC6A4MPO | |
| SCHEMBL31411334 | 0.75 | TAAR1 (0.44) | ARGPR84SLC6A4MPO | |
| SCHEMBL5638323 | 0.73 | AR (0.39) | ARGPR84LMNASLC6A4MPO | |
| SCHEMBL8212290 | 0.73 | KDM4E (0.47) | MAPK10TP53FLT3TRPA1 | |
| SCHEMBL30998058 | 0.72 | AR (0.38) | ARGPR84LMNASLC6A4MPO | |
| SCHEMBL4234184 | 0.72 | ADORA2A (0.41) | ARGPR84LMNASLC6A4MPO | |
| SCHEMBL31411439 | 0.72 | HTR2A (0.48) | ARGPR84SLC6A4MPOPARP1 | |
| Iodide SCHEMBL1595770 | 0.71 | KDM4E (0.46) | MAPK10TP53FLT3TRPA1 | |
| SCHEMBL17515575 | 0.71 | MAPK10 (0.36) | ARGPR84LMNASLC6A4MPO | |
| SCHEMBL14158304 | 0.70 | TNKS (0.44) | GPR84LMNAMAPK10RIPK1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040995-A9 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LTD (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008040995-A1 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |