Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205583 | 1.00 | NPC1 (0.47) | NPC1ASH1LRAB9APARP1KIF11 | |
| SCHEMBL6015914 | 0.86 | NPC1 (0.64) | NPC1ASH1LRAB9APARP1KIF11 | |
| SCHEMBL6015917 | 0.86 | NPC1 (0.64) | NPC1ASH1LRAB9APARP1KIF11 | |
| SCHEMBL1248927 | 0.78 | PIM1 (0.62) | NPC1ASH1LGFER | |
| SCHEMBL1248926 | 0.78 | PIM1 (0.62) | NPC1ASH1LGFER | |
| SCHEMBL12891971 | 0.78 | PIM1 (0.62) | NPC1ASH1LGFER | |
| SCHEMBL212820 | 0.77 | PLG (0.61) | NPC1ASH1LRAB9APARP1KIF11 | |
| SCHEMBL8197809 | 0.76 | PIM1 (0.48) | NPC1ASH1LPARP1KIF11MEN1 | |
| SCHEMBL8197811 | 0.76 | PIM1 (0.48) | NPC1ASH1LPARP1KIF11MEN1 | |
| SCHEMBL5576484 | 0.74 | NTRK1 (0.53) | NPC1RAB9APDGFRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018745-A1 | OXAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |