Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | PRKCI | P41743 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170254 | 0.96 | PDE5A (0.61) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL5779424 | 0.89 | MAPT (0.60) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL7017142 | 0.86 | HTT (0.56) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL7168076 | 0.85 | MAPT (0.56) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL5781751 | 0.83 | RNASEL (0.51) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL7174355 | 0.82 | HTT (0.53) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL7016164 | 0.82 | HTT (0.52) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL7407521 | 0.82 | MAPT (0.54) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL7012571 | 0.82 | MEN1 (0.52) | PDE5AMAPTMEN1KMT2AHTT | |
| SCHEMBL7408659 | 0.81 | PRKCI (0.74) | PRKCIPRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |