Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15087211 | 0.89 | ALDH1A1 (0.52) | ALDH1A1MAPTGAACYP2D6CHRM2 | |
| SCHEMBL1287680 | 0.86 | ALDH1A1 (0.47) | ALDH1A1MAPTGAACYP2D6USP2 | |
| SCHEMBL8905002 | 0.86 | ALDH1A1 (0.47) | ALDH1A1MAPTGAACYP2D6CHRM2 | |
| SCHEMBL686820 | 0.86 | ALDH1A1 (0.47) | ALDH1A1MAPTGAACYP2D6CHRM2 | |
| SCHEMBL14230617 | 0.86 | ALDH1A1 (0.43) | ALDH1A1MAPTGAACYP2D6CHRM2 | |
| SCHEMBL10934229 | 0.85 | MAPT (0.42) | ALDH1A1MAPTGAACYP2D6CHRM2 | |
| SCHEMBL4613994 | 0.85 | ALDH1A1 (0.46) | ALDH1A1MAPTGAACYP2D6USP2 | |
| SCHEMBL29260920 | 0.85 | ALDH1A1 (0.46) | ALDH1A1MAPTGAACYP2D6CHRM2 | |
| SCHEMBL8906026 | 0.85 | ALDH1A1 (0.46) | ALDH1A1MAPTGAACYP2D6CHRM2 | |
| SCHEMBL891457 | 0.84 | ALDH1A1 (0.55) | ALDH1A1MAPTGAACYP2D6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019073431-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2019-04-18 | — | — | WO | claimed |
| WO-2019073431-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2019-04-18 | — | — | WO | disclosed |
| US-6130195-A | TETRAHYDROFURFURYL ALCOHOL AND 3-METHOXY-3-METHYL BUTANOL. | KYZEN CORPORATION (US) | 2000-10-10 | — | — | US | disclosed |