Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.77 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.77 |
| ▸ | PLK4 | O00444 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | EGFR | P00533 | 1/20 | 0.77 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.77 |
| ▸ | ARAF | P10398 | 1/20 | 0.77 |
| ▸ | PIM1 | P11309 | 1/20 | 0.77 |
| ▸ | BRAF | P15056 | 1/20 | 0.77 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.77 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.77 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.77 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.77 |
| ▸ | MYOC | Q99972 | 1/20 | 0.77 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.77 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.77 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.77 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gw305074X SCHEMBL149921 | 0.87 | RAF1 (1.00) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| Gw305074X SCHEMBL149922 | 0.87 | RAF1 (1.00) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| Gw305074X SCHEMBL29392050 | 0.87 | RAF1 (1.00) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| Gw305074X SCHEMBL29389948 | 0.87 | RAF1 (1.00) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| Gw305074X SCHEMBL12199472 | 0.87 | RAF1 (1.00) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| SCHEMBL14519120 | 0.85 | LRRK2 (1.00) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| SCHEMBL5370064 | 0.83 | PSEN1 (0.71) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| SCHEMBL5366800 | 0.83 | MAPT (0.70) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| SCHEMBL10026597 | 0.82 | RAF1 (0.77) | RAF1MAP1LC3BMAPTPLK4MEN1 | |
| SCHEMBL26245253 | 0.82 | RAF1 (0.77) | RAF1MAP1LC3BMAPTPLK4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |