Gw305074X

Gw305074X

SCHEMBL149922

O=C1Nc2ccc(I)cc2C1=Cc1cc(Br)c(O)c(Br)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 12/20 1.00
MAP1LC3B Q9GZQ8 3/20 1.00
MAPT P10636 3/20 1.00
EGFR P00533 1/20 1.00
NTRK1 P04629 1/20 1.00
ARAF P10398 1/20 1.00
PIM1 P11309 1/20 1.00
BRAF P15056 1/20 1.00
CSNK2A1 P68400 1/20 1.00
PIM3 Q86V86 1/20 1.00
SIRT2 Q8IXJ6 1/20 1.00
SIRT1 Q96EB6 1/20 1.00
MYOC Q99972 1/20 1.00
DYRK4 Q9NR20 1/20 1.00
SIRT3 Q9NTG7 1/20 1.00
SIRT5 Q9NXA8 1/20 1.00
MAP3K20 Q9NYL2 1/20 1.00
PIM2 Q9P1W9 1/20 1.00
RIPK3 Q9Y572 1/20 1.00
MEN1 O00255 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gw305074X SCHEMBL12199472 1.00 RAF1 (1.00) RAF1MAP1LC3BMAPTEGFRNTRK1
Gw305074X SCHEMBL29389948 1.00 RAF1 (1.00) RAF1MAP1LC3BMAPTEGFRNTRK1
Gw305074X SCHEMBL149921 1.00 RAF1 (1.00) RAF1MAP1LC3BMAPTEGFRNTRK1
Gw305074X SCHEMBL29392050 1.00 RAF1 (1.00) RAF1MAP1LC3BMAPTEGFRNTRK1
SCHEMBL5367163 0.89 RAF1 (0.79) RAF1MAP1LC3BMAPTEGFRNTRK1
SCHEMBL1394784 0.89 RAF1 (0.79) RAF1MAP1LC3BMAPTEGFRNTRK1
SCHEMBL4726411 0.89 RAF1 (0.79) RAF1MAP1LC3BMAPTEGFRNTRK1
SCHEMBL8206335 0.87 RAF1 (0.77) RAF1MAP1LC3BMAPTEGFRNTRK1
SCHEMBL26245253 0.87 RAF1 (0.77) RAF1MAP1LC3BMAPTEGFRNTRK1
SCHEMBL10026597 0.87 RAF1 (0.77) RAF1MAP1LC3BMAPTEGFRNTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 418 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220047552-A1 RAF-1 KINASE INHIBITOR COMPOUNDS FOR SKELETAL MUSCLE MODULATION, METHODS AND USES THEREOF NESTLE SA (CH) 2022-02-17 US claimed
EP-3852742-A1 RAF-1 KINASE INHIBITOR COMPOUNDS FOR SKELETAL MUSCLE MODULATION, METHODS AND USES THEREOF Société des Produits Nestlé S.A. (CH) 2021-07-28 EP claimed
CN-112654355-A RAF-1 kinase inhibitor compounds for skeletal muscle modulation, methods and uses thereof 雀巢产品有限公司 2021-04-13 CN claimed
EP-3222276-B1 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER AND BIOMARKER FOR DRUG SCREENING NAT DEFENSE MEDICAL CENTER (CN) 2021-04-07 EP claimed
WO-2020058071-A1 RAF-1 KINASE INHIBITOR COMPOUNDS FOR SKELETAL MUSCLE MODULATION, METHODS AND USES THEREOF Société des Produits Nestlé S.A. (CH) 2020-03-26 WO claimed
EP-2879675-B1 COMPOUNDS AND METHODS FOR TARGETING HSP90 UNIV DUKE (US) 2019-11-13 EP claimed
US-20180186885-A1 FZD7 SPECIFIC ANTIBODIES AND VACCINES TO TREAT CANCER AND CONTROL STEM CELL FUNCTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-07-05 US claimed
US-9782393-B2 Pharmaceutical compositions and methods for treating cancer and biomarkers for drug screening NATIONAL DEFENSE MEDICAL CENTER (TW) 2017-10-10 US claimed
EP-3222276-A1 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER AND BIOMARKER FOR DRUG SCREENING National Defense Medical Center (CN) 2017-09-27 EP claimed
WO-2016205551-A2 FZD7 SPECIFIC ANTIBODIES AND VACCINES TO TREAT CANCER AND CONTROL STEM CELL FUNCTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-12-22 WO claimed
US-9393234-B2 Pharmaceutical compositions and methods for treating cancer and biomarkers for drug screening NATIONAL DEFENSE MEDICAL CENTER (TW) 2016-07-19 US claimed
US-20150150859-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING CANCER AND BIOMARKERS FOR DRUG SCREENING NAT DEFENSE MEDICAL CT (TW) 2015-06-04 US claimed
US-20140357676-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING CANCER AND BIOMARKERS FOR DRUG SCREENING NATIONAL DEFENSE MEDICAL CENTER (TW) 2014-12-04 US claimed
US-20130266636-A1 METHODS FOR BLOCKING CELL PROLIFERATION AND TREATING DISEASES AND CONDITIONS RESPONSIVE TO CELL GROWTH INHIBITION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-10-10 US claimed
WO-2012021778-A2 METHODS FOR BLOCKING CELL PROLIFERATION AND TREATING DISEASES AND CONDITIONS RESPONSIVE TO CELL GROWTH INHIBITION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-16 WO claimed
US-20100272717-A1 COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER NOVARTIS AG (CH) 2010-10-28 US claimed
US-20060194769-A1 Small molecules that reduce fungal growth UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2006-08-31 US claimed
WO-2006081327-A2 SMALL MOLECULES THAT REDUCE FUNGAL GROWTH UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2006-08-03 WO claimed
US-20050250837-A1 Use of C-Raf inhibitors for the treatment of neurodegenerative diseases BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2005-11-10 US claimed
WO-2004064733-A2 THE USE OF C-RAF INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2004-08-05 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140357676-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING CANCER AND BIOMARKERS FOR DRUG SCREENING DAPK1, DAPK2, ARAF RAF1 5/4885MAP1LC3B 2273/4885MAPT 4268/4885
US-20060194769-A1 Small molecules that reduce fungal growth ERG28, DPM1, CYP51A1 RAF1 2317/4885MAP1LC3B 661/4885MAPT 1481/4885
US-20100272717-A1 COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER ANXA5, BAX, ANXA6 RAF1 2033/4885MAP1LC3B 3069/4885MAPT 4379/4885
US-20150150859-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING CANCER AND BIOMARKERS FOR DRUG SCREENING ARAF, DAPK1, DAPK2 RAF1 5/4885MAP1LC3B 2223/4885MAPT 4165/4885
US-20050250837-A1 Use of C-Raf inhibitors for the treatment of neurodegenerative diseases BRAF, RAF1, ARAF RAF1 2/4885MAP1LC3B 999/4885MAPT 812/4885
US-20220047552-A1 RAF-1 KINASE INHIBITOR COMPOUNDS FOR SKELETAL MUSCLE MODULATION, METHODS AND USES THEREOF MYLK2, RAF1, MUSK RAF1 2/4885MAP1LC3B 1008/4885MAPT 4734/4885
US-20130266636-A1 METHODS FOR BLOCKING CELL PROLIFERATION AND TREATING DISEASES AND CONDITIONS RESPONSIVE TO CELL GROWTH INHIBITION BRAF, BUB1B, MKI67 RAF1 25/4885MAP1LC3B 640/4885MAPT 2064/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.