Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11924768 | 0.84 | MEN1 (0.39) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8213836 | 0.78 | MEN1 (0.38) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL12807332 | 0.77 | ADORA2A (0.36) | ADORA2AADORA1 | |
| SCHEMBL8213853 | 0.76 | POLB (0.48) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8214424 | 0.69 | BACE1 (0.40) | KDM4EALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL11924667 | 0.69 | PIK3CA (0.47) | ALDH1A1MAPTMEN1KMT2AADORA2A | |
| SCHEMBL8221459 | 0.69 | PLK4 (0.45) | KDM4EMAP4K4MKNK2 | |
| SCHEMBL11925498 | 0.69 | MEN1 (0.45) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL1091668 | 0.67 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL31158163 | 0.67 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |