Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.46 |
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11925421 | 0.84 | POLB (0.48) | POLBPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8102170 | 0.80 | CA2 (0.49) | POLBPIK3CAPIK3CDALDH1A1MEN1 | |
| SCHEMBL11926034 | 0.79 | ALDH1A1 (0.43) | POLBPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL11925324 | 0.77 | PIK3CA (0.42) | POLBPIK3CAPIK3CDMTORMEN1 | |
| SCHEMBL8206492 | 0.76 | KDM4E (0.44) | ALDH1A1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL7920061 | 0.76 | PIK3CA (0.47) | POLBPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8217414 | 0.74 | MTOR (0.52) | POLBPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL3061831 | 0.73 | PIK3CA (0.81) | PIK3CAPIK3CDMTORATR | |
| SCHEMBL8096450 | 0.73 | KMT2A (0.53) | PIK3CAPIK3CDMTORMEN1MAPT | |
| SCHEMBL8205071 | 0.72 | PIK3CA (0.54) | POLBPIK3CAPIK3CDMTORALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |