Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | BCL9 | O00512 | 3/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218681 | 0.92 | AKR1C3 (0.51) | AKR1C3AKR1C1DPP4LMNASMN1; SMN2 | |
| SCHEMBL8214083 | 0.91 | LMNA (0.47) | AKR1C3AKR1C1DPP4LMNASMN1; SMN2 | |
| SCHEMBL8216785 | 0.88 | POLB (0.50) | AKR1C3LMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8288233 | 0.84 | DPP4 (0.46) | AKR1C3AKR1C1DPP4LMNASMN1; SMN2 | |
| SCHEMBL8214183 | 0.82 | EPHX2 (0.41) | AKR1C3AKR1C1DPP4LMNASMN1; SMN2 | |
| SCHEMBL8216780 | 0.82 | MAPT (0.52) | LMNAALDH1A1GAAPREP | |
| SCHEMBL8218638 | 0.80 | PREP (0.45) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8218676 | 0.79 | AKR1C3 (0.55) | AKR1C3AKR1C1LMNAALDH1A1USP2 | |
| SCHEMBL16104911 | 0.77 | LMNA (0.48) | AKR1C3AKR1C1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8214993 | 0.77 | PREP (0.39) | AKR1C3DPP4FAPDPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825139-B2 | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV | Forest Laboratories Holdings Limited (BM) | 2010-11-02 | — | — | US | disclosed |
| US-7825139-B2 | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV | Forest Laboratories Holdings Limited (BM) | 2010-11-02 | — | — | US | disclosed |
| US-20060276410-A1 | COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | Forest Laboratories Holding Limited (BM) | 2006-12-07 | — | — | US | disclosed |
| US-20060276410-A1 | COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | Forest Laboratories Holding Limited (BM) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276410-A1 | COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | DPP4, DPP3, DPP7 | AKR1C3 905/4885AKR1C1 1170/4885CNR1 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.