Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 16/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5677771 | 0.81 | MAP2K4 (0.51) | MAP2K4MAP2K7MAPK1MAPK6ITK | |
| SCHEMBL5953156 | 0.78 | MAP2K4 (0.51) | MAP2K4MAP2K7MAPK1MAPK6ITK | |
| SCHEMBL19570332 | 0.78 | MAP2K4 (0.51) | MAP2K4MAP2K7MAPK1MAPK6ITK | |
| SCHEMBL8212290 | 0.76 | KDM4E (0.47) | — | |
| SCHEMBL7713988 | 0.75 | MAP2K4 (0.49) | MAP2K4MAP2K7MAPK1MAPK6ITK | |
| Iodide SCHEMBL1595770 | 0.75 | KDM4E (0.46) | — | |
| SCHEMBL19570331 | 0.74 | MAP2K4 (0.47) | MAP2K4MAP2K7MAPK1MAPK6ITK | |
| SCHEMBL30982343 | 0.73 | MAP2K4 (0.46) | MAP2K4MAP2K7MAPK1MAPK6ITK | |
| SCHEMBL5635008 | 0.73 | MAP2K4 (0.46) | MAP2K4MAP2K7MAPK1MAPK6ITK | |
| SCHEMBL14979221 | 0.73 | MAP2K4 (0.54) | MAP2K4MAP2K7MAPK1MAPK6ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040995-A9 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LTD (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008040995-A1 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |