Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 15/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8147564 | 0.84 | ADK (0.68) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8207402 | 0.81 | ADK (1.00) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8138291 | 0.78 | ADK (0.57) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8196795 | 0.78 | ADK (0.63) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8138288 | 0.78 | ADK (0.58) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL2038471 | 0.76 | ADK (0.72) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL2032548 | 0.76 | ADK (0.72) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8127996 | 0.75 | ADK (0.78) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL2049243 | 0.75 | ADK (0.62) | ADKKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL2039883 | 0.74 | ADK (0.77) | ADKKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | claimed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |