Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.35 |
| ▸ | HRH1 | P35367 | 5/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206421 | 0.75 | MAOA (0.41) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL27656805 | 0.69 | MAOA (0.44) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL1521526 | 0.69 | MAOA (0.41) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL8207219 | 0.69 | MAOA (0.41) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL8216855 | 0.69 | — | — | |
| SCHEMBL3213057 | 0.68 | MAOA (0.58) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL3213890 | 0.68 | MAOA (0.43) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL27831839 | 0.68 | MAOA (0.40) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL28059116 | 0.68 | MAOB (0.46) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL4630893 | 0.66 | MAOA (0.41) | MAOAMAOBCYP3A4CYP2D6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | claimed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |