SCHEMBL8207252

SCHEMBL8207252

COc1cccc2cc(C(=O)O)c(O)cc12

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.77
ALDH1A1 P00352 3/20 0.77
HPGD P15428 3/20 0.77
HSD17B10 Q99714 3/20 0.77
GRIN2D O15399 1/20 0.66
GRIN2A Q12879 1/20 0.66
GRIN2B Q13224 1/20 0.66
GRIN2C Q14957 1/20 0.66
CA12 O43570 2/20 0.57
CA1 P00915 2/20 0.57
CA2 P00918 2/20 0.57
CA7 P43166 2/20 0.57
CA9 Q16790 2/20 0.57
CA14 Q9ULX7 2/20 0.57
CA3 P07451 1/20 0.57
CA4 P22748 1/20 0.57
CA6 P23280 1/20 0.57
CA5A P35218 1/20 0.57
CA5B Q9Y2D0 1/20 0.57
MEN1 O00255 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL164671 0.89 ALDH1A1 (0.84) KDM4EALDH1A1HPGDHSD17B10GRIN2D
SCHEMBL29450082 0.89 ALDH1A1 (0.84) KDM4EALDH1A1HPGDHSD17B10GRIN2D
SCHEMBL551105 0.87 ALDH1A1 (1.00) KDM4EALDH1A1HPGDHSD17B10GRIN2D
SCHEMBL29353299 0.87 ALDH1A1 (1.00) KDM4EALDH1A1HPGDHSD17B10GRIN2D
SCHEMBL5344077 0.86 KDM4E (0.61) KDM4EALDH1A1HPGDHSD17B10GRIN2D
SCHEMBL10390227 0.85 GRIN2D (0.62) KDM4EALDH1A1HPGDHSD17B10GRIN2D
SCHEMBL8126323 0.84 ALDH1A1 (0.88) KDM4EALDH1A1HPGDHSD17B10GRIN2D
SCHEMBL12521444 0.82 KMT2A (0.62) KDM4EALDH1A1HPGDHSD17B10MEN1
SCHEMBL24895096 0.81 KDM4E (0.59) KDM4EALDH1A1HPGDHSD17B10GRIN2D
SCHEMBL29620158 0.81 ALDH1A1 (0.77) KDM4EALDH1A1HPGDHSD17B10GRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0836592-A1 AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES F. HOFFMANN-LA ROCHE AG (CH) 1998-04-22 EP claimed
WO-1997002249-A1 NOVEL AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES F. HOFFMANN-LA ROCHE AG (CH) 1997-01-23 WO claimed
US-4948582-A PRETREATMENT WITH AN OXYNAPHTHOIC ACID DERIVATIVE RORER PHARMACEUTICAL CORPORATION (US) 1990-08-14 US claimed
EP-0347932-A2 Treatment of conditions requiring enhanced oxygen availability to mammalian tissues RORER INTERNATIONAL (OVERSEAS) INC. (US) 1989-12-27 EP claimed
US-4861795-A USING NAPHTHOIC ACID DERIVATIVE RORER PHARMACEUTICAL CORPORATION (US) 1989-08-29 US claimed
US-6136969-A PROTEIN KINASE INHIBITORS; 4-HYDROXYBENZOIC ACID 3-(4-(4-FLUOROBENZOYLOXY)-BENZOYLAMINO)-AZEPAN-4-YL ESTER HOFFMANN-LA ROCHE INC. (US) 2000-10-24 US disclosed
US-5907038-A PROTEIN KINASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 1999-05-25 US disclosed
US-5830920-A PREVENTION GROWTH OF SMOOTH MUSCLE CELLS HOFFMANN-LA ROCHE INC. (US) 1998-11-03 US disclosed
EP-0836592-A1 AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES F. HOFFMANN-LA ROCHE AG (CH) 1998-04-22 EP disclosed
WO-1997002249-A1 NOVEL AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES F. HOFFMANN-LA ROCHE AG (CH) 1997-01-23 WO disclosed
EP-0347932-A2 Treatment of conditions requiring enhanced oxygen availability to mammalian tissues RORER INTERNATIONAL (OVERSEAS) INC. (US) 1989-12-27 EP disclosed
US-4861795-A USING NAPHTHOIC ACID DERIVATIVE RORER PHARMACEUTICAL CORPORATION (US) 1989-08-29 US disclosed