Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.45 |
| ▸ | EDNRB | P24530 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658049 | 0.85 | EDNRA (0.59) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL7658046 | 0.85 | EDNRA (0.59) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL6950719 | 0.84 | RAB9A (0.52) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL6950723 | 0.84 | RAB9A (0.52) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL8207341 | 0.79 | CFTR (0.39) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL6955353 | 0.77 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL7533884 | 0.76 | RAB9A (0.51) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL7383029 | 0.76 | RAB9A (0.51) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL7383032 | 0.76 | RAB9A (0.51) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL7533871 | 0.75 | MAOB (0.51) | EDNRAEDNRBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6087389-A | TREATING CARDIOVASCULAR AND RENAL DISEASES INCLUDING HYPERTENSION, ACUTE AND CHRONIC RENAL FAILURE, CYCLOSPORINE INDUCED NEPHROTOXICITY, STROKE, CEREBROVASCULAR VASOSPASM, MYOCARDIAL ISCHEMIA, ANGINA, HEART FAILURE, ATHEROSCLEROSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-11 | — | — | US | disclosed |