Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207351 | 1.00 | PIM1 (0.48) | PIM1TDP1NPC1PIK3CGPIK3CA | |
| SCHEMBL1248926 | 0.89 | PIM1 (0.62) | PIM1TDP1NPC1PIK3CGPIK3CA | |
| SCHEMBL12891971 | 0.89 | PIM1 (0.62) | PIM1TDP1NPC1PIK3CGPIK3CA | |
| SCHEMBL1248927 | 0.89 | PIM1 (0.62) | PIM1TDP1NPC1PIK3CGPIK3CA | |
| SCHEMBL8197811 | 0.85 | PIM1 (0.48) | PIM1NPC1PIK3CGPIK3CAASH1L | |
| SCHEMBL8197809 | 0.85 | PIM1 (0.48) | PIM1NPC1PIK3CGPIK3CAASH1L | |
| SCHEMBL8209418 | 0.75 | NTRK1 (0.48) | TDP1NPC1PIK3CAPDGFRB | |
| SCHEMBL8209417 | 0.75 | NTRK1 (0.48) | TDP1NPC1PIK3CAPDGFRB | |
| SCHEMBL212820 | 0.75 | PLG (0.61) | PIM1NPC1ASH1LKIF11PARP1 | |
| SCHEMBL1247737 | 0.74 | HPGD (0.46) | PIM1NPC1PIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |