Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14158639 | 0.86 | MAP2K4 (0.40) | SCN9ASCN5AMAP2K4SSTR4L3MBTL1 | |
| SCHEMBL16149702 | 0.85 | SCN9A (0.37) | SCN9ASCN5AMAP2K4ELANESSTR4 | |
| SCHEMBL14240104 | 0.84 | SCN9A (0.37) | SCN9ASCN5AMAP2K4SSTR4BCHE | |
| SCHEMBL8213133 | 0.84 | SCN9A (0.34) | SCN9ASCN5AMAP2K4ELANEBCHE | |
| SCHEMBL8215915 | 0.82 | SCN9A (0.36) | SCN9ASCN5AMAP2K4SSTR4L3MBTL1 | |
| SCHEMBL8218069 | 0.81 | FAAH (0.35) | SCN9ASCN5AMAP2K4ELANEBCHE | |
| SCHEMBL31460467 | 0.80 | USP30 (0.37) | SCN9ASCN5AMAP2K4ELANEL3MBTL1 | |
| SCHEMBL31460540 | 0.78 | MAP2K4 (0.34) | SCN9AMAP2K4GPR119FAAHRORC | |
| SCHEMBL8216089 | 0.77 | ELANE (0.52) | SCN9AMAP2K4ELANEL3MBTL1BCHE | |
| SCHEMBL30438541 | 0.74 | CYP11B1 (0.43) | SCN9ASCN5AELANEBCHETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968316-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |
| WO-2008040995-A9 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LTD (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008040995-A1 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |