SCHEMBL8207399

SCHEMBL8207399

O=C1CC(=O)OC(c2ccccc2)O1.[SiH4]

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
LMNA P02545 1/20 0.47
POLB P06746 1/20 0.47
SIRT1 Q96EB6 11/20 0.42
CYP2C19 P33261 2/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C9 P11712 1/20 0.40
KDM4E B2RXH2 1/20 0.39
ADORA3 P0DMS8 1/20 0.39
AR P10275 1/20 0.39
CYP19A1 P11511 1/20 0.39
MAOB P27338 1/20 0.39
HSD17B10 Q99714 1/20 0.39
CA2 P00918 1/20 0.38
ALDH1A1 P00352 1/20 0.38
SIRT2 Q8IXJ6 2/20 0.38
SIRT5 Q9NXA8 2/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL120709 0.98 MEN1 (0.48) MEN1KMT2ALMNAPOLBSIRT1
SCHEMBL5186156 0.90 MEN1 (0.43) MEN1KMT2ALMNAPOLBSIRT1
Malonic Acid SCHEMBL18092161 0.85 KMT2A (0.40) MEN1KMT2ALMNAPOLBSIRT1
SCHEMBL28375248 0.85 MEN1 (0.40) MEN1KMT2ALMNAPOLBSIRT1
1,3-Propanediol SCHEMBL743614 0.85 MEN1 (0.40) MEN1KMT2ALMNAPOLBSIRT1
SCHEMBL7379470 0.84 MEN1 (0.48) MEN1KMT2ALMNAPOLBSIRT1
SCHEMBL27883738 0.79 MEN1 (0.49) MEN1KMT2ALMNAPOLBSIRT1
SCHEMBL30236541 0.79 TP53 (0.46) MEN1KMT2ALMNAPOLBSIRT1
SCHEMBL28000731 0.78 MAOB (0.35) MEN1KMT2ALMNAPOLBSIRT1
SCHEMBL8079034 0.77 MEN1 (0.45) MEN1KMT2ALMNAPOLBSIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10324620-A None JP disclosed
JP-10324620-A None JP disclosed
JP-2000136120-A METHOD FOR IMPROVING LIGHT STABILITY OF DIBENZOYLMETHANE DERIVATIVE WITH BENZAL MALONATE SILANE AND LIGHT STABILITY IMPROVING AGENT L'OREAL SA 2000-05-16 JP disclosed
JP-2000136120-A METHOD FOR IMPROVING LIGHT STABILITY OF DIBENZOYLMETHANE DERIVATIVE WITH BENZAL MALONATE SILANE AND LIGHT STABILITY IMPROVING AGENT L'OREAL SA 2000-05-16 JP disclosed
JP-H10324620-A IMPROVEMENT FOR PHOTOSTABILIZATION OF BENZOYLMETHANE DERIVATIVE BY BENZAL MALONATE SILANE AND PRODUCTION OF BENZAL MALONATE SILANE L'OREAL SA 1998-12-08 JP disclosed
JP-H10324620-A IMPROVEMENT FOR PHOTOSTABILIZATION OF BENZOYLMETHANE DERIVATIVE BY BENZAL MALONATE SILANE AND PRODUCTION OF BENZAL MALONATE SILANE L'OREAL SA 1998-12-08 JP disclosed