Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN2 | P17655 | 12/20 | 1.00 |
| ▸ | CTSB | P07858 | 2/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.52 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.52 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.52 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.52 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.52 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.52 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.52 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.52 |
| ▸ | PSMA6 | P60900 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12943157 | 0.99 | CAPN2 (1.00) | CAPN2CTSBPSMB11PSMA7CAPN1 | |
| SCHEMBL931241 | 0.92 | CAPN2 (0.85) | CAPN2CTSBPSMB11PSMA7CAPN1 | |
| SCHEMBL12943083 | 0.91 | CAPN2 (0.83) | CAPN2CTSBPSMB11PSMA7CAPN1 | |
| SCHEMBL12943161 | 0.90 | CAPN2 (0.84) | CAPN2CTSBPSMB11PSMA7CAPN1 | |
| SCHEMBL8206132 | 0.90 | CAPN2 (0.82) | CAPN2MMP1MMP2MMP3MMP7 | |
| SCHEMBL8195187 | 0.90 | CAPN2 (0.88) | CAPN2CTSBPSMB11PSMA7CAPN1 | |
| SCHEMBL15869914 | 0.90 | CAPN2 (0.82) | CAPN2CTSBPSMB11PSMA7CAPN1 | |
| SCHEMBL15869911 | 0.90 | CAPN2 (0.81) | CAPN2CTSBPSMB11PSMA7CAPN1 | |
| SCHEMBL12943114 | 0.89 | CAPN2 (0.86) | CAPN2CTSBPSMB11PSMA7CAPN1 | |
| SCHEMBL930997 | 0.89 | CAPN2 (0.80) | CAPN2CTSBPSMB11PSMA7CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9434762-B2 | Macrocyclic cysteine protease inhibitors and compositions thereof | UNIVERSITY OF CANTERBURY (NZ) | 2016-09-06 | — | — | US | disclosed |
| US-20140194362-A1 | Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof | LINCOLN UNIVERSITY (NZ) | 2014-07-10 | — | — | US | disclosed |
| US-20110021434-A1 | Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof | UNIVERSITY OF CANTERBURY (NZ) | 2011-01-27 | — | — | US | disclosed |
| WO-2008048121-A2 | MACROCYCLIC CYSTEINE PROTEASE INHIBITORS AND COMPOSITIONS THEREOF | LINCOLN UNIVERSITY (NZ) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194362-A1 | Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof | CAPNS1, CAPN1, CAPN9 | CAPN2 4/4885CTSB 11/4885PSMB11 171/4885 |
| US-20110021434-A1 | Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof | CAPNS1, CAPN1, CAPN9 | CAPN2 4/4885CTSB 11/4885PSMB11 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.