Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN2 | P17655 | 9/20 | 0.49 |
| ▸ | TMPRSS2 | O15393 | 4/20 | 0.43 |
| ▸ | F2 | P00734 | 4/20 | 0.43 |
| ▸ | HPN | P05981 | 4/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.43 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.41 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.41 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.41 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12943167 | 0.93 | CAPN2 (0.47) | CAPN2TMPRSS2F2HPNST14 | |
| SCHEMBL8209212 | 0.87 | CAPN2 (0.48) | CAPN2TMPRSS2F2HPNST14 | |
| SCHEMBL12943280 | 0.87 | CAPN2 (0.48) | CAPN2TMPRSS2F2HPNST14 | |
| SCHEMBL17884328 | 0.85 | CAPN2 (0.49) | CAPN2TMPRSS2F2HPNST14 | |
| SCHEMBL12943281 | 0.83 | CAPN2 (0.49) | CAPN2TMPRSS2F2HPNST14 | |
| SCHEMBL931569 | 0.82 | CAPN2 (0.55) | CAPN2TMPRSS2F2HPNST14 | |
| SCHEMBL17884315 | 0.81 | CTSD (0.49) | CAPN2CTSDBACE1 | |
| SCHEMBL929429 | 0.79 | CAPN2 (0.60) | CAPN2TMPRSS2F2HPNST14 | |
| SCHEMBL12943118 | 0.79 | CAPN2 (0.51) | CAPN2TMPRSS2F2HPNST14 | |
| SCHEMBL17884332 | 0.79 | CAPN2 (0.51) | CAPN2TMPRSS2F2HPNST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008048121-A2 | MACROCYCLIC CYSTEINE PROTEASE INHIBITORS AND COMPOSITIONS THEREOF | LINCOLN UNIVERSITY (NZ) | 2008-04-24 | — | — | WO | disclosed |