Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | LPL | P06858 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL958345 | 0.97 | TP53 (0.48) | TP53TAAR1CYP2A6HTR2AALDH1A1 | |
| SCHEMBL149101 | 0.94 | — | — | |
| SCHEMBL4847965 | 0.92 | TP53 (0.48) | TP53TAAR1CYP2A6HTR2AALDH1A1 | |
| Ethylene SCHEMBL27607024 | 0.89 | TP53 (0.46) | TP53TAAR1CYP2A6HTR2AALDH1A1 | |
| Methoxymethane SCHEMBL27325845 | 0.86 | IDO1 (0.46) | TP53TAAR1CYP2A6HTR2AALDH1A1 | |
| Formaldehyde SCHEMBL27868886 | 0.86 | ALDH1A1 (0.46) | TP53TAAR1CYP2A6HTR2AALDH1A1 | |
| SCHEMBL2479806 | 0.86 | MAPK1 (0.48) | TP53TAAR1CYP2A6HTR2AALDH1A1 | |
| SCHEMBL17166204 | 0.82 | TAAR1 (0.45) | TP53TAAR1CYP2A6HTR2AALDH1A1 | |
| SCHEMBL12514357 | 0.82 | TAAR1 (0.45) | TP53TAAR1CYP2A6HTR2AALDH1A1 | |
| SCHEMBL30367150 | 0.82 | TAAR1 (0.45) | TP53TAAR1CYP2A6HTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109973-A1 | PEROVSKITE METAL HALIDE ZERO-DIMENSIONAL QUANTUM DOT COMPOSITE MATERIAL AND PREPARATION METHOD THEREFOR, AND USE OF ORGANIC AMINE SALT | 南开大学 | 2023-06-22 | — | — | WO | disclosed |
| CN-1058709-C | Amide compounds for medical treatment | PFIZER (US) | 2000-11-22 | — | — | CN | disclosed |
| US-6121283-A | Apo B-secretion/MTP inhibitory amides | PFIZER INC (US) | 2000-09-19 | — | — | US | disclosed |
| CN-1141918-A | Amide compounds for medical treatment | PFIZER (US) | 1997-02-05 | — | — | CN | disclosed |