Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 1.00 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | GLS2 | Q9UI32 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209251 | 1.00 | GSK3B (1.00) | GSK3BCGASSMN1; SMN2MAPTLMNA | |
| SCHEMBL8209256 | 1.00 | GSK3B (1.00) | GSK3BCGASSMN1; SMN2MAPTLMNA | |
| SCHEMBL12821680 | 0.79 | GSK3B (0.81) | GSK3BCGASSMN1; SMN2MAPTLMNA | |
| SCHEMBL12821679 | 0.79 | GSK3B (0.81) | GSK3BCGASSMN1; SMN2MAPTLMNA | |
| SCHEMBL12258530 | 0.78 | GSK3B (0.65) | GSK3BCGASSMN1; SMN2MAPTLMNA | |
| SCHEMBL10596632 | 0.78 | GSK3B (0.65) | GSK3BCGASSMN1; SMN2MAPTLMNA | |
| SCHEMBL10596629 | 0.78 | GSK3B (0.65) | GSK3BCGASSMN1; SMN2MAPTLMNA | |
| SCHEMBL8956489 | 0.77 | GSK3B (0.63) | GSK3BDYRK1AMEN1KMT2AHDAC2 | |
| SCHEMBL8544793 | 0.74 | GSK3B (0.59) | GSK3BCGASSMN1; SMN2MAPTLMNA | |
| SCHEMBL8544791 | 0.74 | GSK3B (0.59) | GSK3BCGASSMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188130-B1 | Anti-cancer hydantoin compounds and methods | UNIVERSITY OF LOUISIANA AT MONROE (US) | 2012-05-29 | — | — | US | claimed |
| US-8188130-B1 | Anti-cancer hydantoin compounds and methods | UNIVERSITY OF LOUISIANA AT MONROE (US) | 2012-05-29 | — | — | US | disclosed |