Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 6/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206710 | 0.95 | TMEM97 (0.39) | DRD2DRD3TRPV1F10TMEM97 | |
| SCHEMBL8206008 | 0.93 | TMEM97 (0.38) | DRD2DRD3TRPV1F10TMEM97 | |
| SCHEMBL8206010 | 0.93 | F10 (0.42) | DRD2DRD3F10TMEM97SIGMAR1 | |
| SCHEMBL8205988 | 0.90 | ACVR1 (0.43) | F10ACVR1LCKJAK3 | |
| SCHEMBL8205845 | 0.90 | HDAC1 (0.41) | DRD2DRD3TMEM97SIGMAR1 | |
| SCHEMBL8209425 | 0.89 | S1PR1 (0.35) | DRD2DRD3F10ACVR1LCK | |
| SCHEMBL8203780 | 0.88 | SIGMAR1 (0.44) | DRD2DRD3TMEM97SIGMAR1 | |
| SCHEMBL8193280 | 0.88 | HDAC6 (0.42) | F10ACVR1LCKJAK3 | |
| SCHEMBL8193482 | 0.88 | ITK (0.41) | TRPV1ACVR1LCKJAK3 | |
| SCHEMBL8198832 | 0.87 | HDAC6 (0.43) | DRD2DRD3ACVR1LCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052934-A1 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-05-08 | — | — | WO | disclosed |