Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202021 | 0.85 | USP30 (0.37) | USP30RORCBACE1NR1H2NR1H3 | |
| SCHEMBL17792475 | 0.84 | USP30 (0.44) | USP30RORCBACE1NR1H2NR1H3 | |
| SCHEMBL31661168 | 0.82 | USP30 (0.41) | USP30RORCBACE1NR1H2NR1H3 | |
| SCHEMBL8210497 | 0.78 | HDAC1 (0.34) | USP30KDM1AKDM4E | |
| SCHEMBL30805912 | 0.74 | USP30 (0.39) | USP30RORCBACE1KRASFPR2 | |
| SCHEMBL16721279 | 0.74 | USP30 (0.43) | USP30RORCBACE1UCHL1FPR2 | |
| SCHEMBL16721274 | 0.74 | USP30 (0.43) | USP30RORCBACE1UCHL1FPR2 | |
| SCHEMBL20131490 | 0.74 | MEN1 (0.35) | USP30UCHL1FPR2KDM4E | |
| SCHEMBL16721581 | 0.73 | USP30 (0.42) | USP30RORCBACE1NR1H2NR1H3 | |
| SCHEMBL31694093 | 0.73 | USP30 (0.40) | USP30RORCBACE1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033744-A2 | DNA METHYL TRANSFERASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |