⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494730 | 1.00 | — | — | |
| SCHEMBL23669312 | 1.00 | — | — | |
| SCHEMBL16635574 | 1.00 | — | — | |
| SCHEMBL3494733 | 1.00 | — | — | |
| SCHEMBL19285478 | 0.81 | MEN1 (0.33) | — | |
| SCHEMBL19284983 | 0.81 | MEN1 (0.33) | — | |
| SCHEMBL19302238 | 0.81 | MEN1 (0.33) | — | |
| SCHEMBL3828941 | 0.75 | FAAH (0.32) | — | |
| SCHEMBL1074342 | 0.75 | FAAH (0.32) | — | |
| SCHEMBL1074340 | 0.75 | FAAH (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303341-B1 | FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL FOR TREATING HIV INFECTION | MERCK SHARP & DOHME (US) | 2020-11-18 | — | — | EP | disclosed |
| US-10233193-B2 | Fused tricyclic heterocyclic compounds useful for treating HIV infection | MERCK SHARP & DOHME CORP. (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180194774-A1 | Fused Tricyclic Heterocyclic Compounds Useful For Treating HIV Infection | MERCK SHARP & DOHME CORP. (US) | 2018-07-12 | — | — | US | disclosed |
| US-20180194774-A1 | Fused Tricyclic Heterocyclic Compounds Useful For Treating HIV Infection | MERCK SHARP & DOHME CORP. (US) | 2018-07-12 | — | — | US | disclosed |
| WO-2016191239-A1 | FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL FOR TREATING HIV INFECTION | MERCK SHARP & DOHME CORP. (US) | 2016-12-01 | — | — | WO | disclosed |
| WO-2008051514-A2 | HCV NS3 PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 2008-05-02 | — | — | WO | disclosed |