Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209468 | 1.00 | MEN1 (0.37) | MEN1KMT2ASLC6A4SLC6A3GRM2 | |
| SCHEMBL8228848 | 0.91 | GRM2 (0.38) | MEN1KMT2AGRM2NAMPTPOLB | |
| SCHEMBL8228850 | 0.91 | GRM2 (0.38) | MEN1KMT2AGRM2NAMPTPOLB | |
| SCHEMBL7711906 | 0.85 | KDM4E (0.38) | SLC6A4SLC6A3GRM2PTGS1NAMPT | |
| SCHEMBL7709044 | 0.85 | KDM4E (0.38) | SLC6A4SLC6A3GRM2PTGS1NAMPT | |
| SCHEMBL8271519 | 0.79 | SLC6A4 (0.37) | SLC6A4SLC6A3PTGS1NAMPTKDM4E | |
| SCHEMBL8203846 | 0.78 | FNTA (0.38) | — | |
| SCHEMBL8203847 | 0.78 | FNTA (0.38) | — | |
| SCHEMBL7241558 | 0.77 | KDM4E (0.43) | KDM4ESMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL7241553 | 0.77 | KDM4E (0.43) | KDM4ESMN1; SMN2NPC1RAB9ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |