Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709044 | 1.00 | KDM4E (0.38) | KDM4EAHRNPSR1CYP19A1SLC6A4 | |
| SCHEMBL7241553 | 0.92 | KDM4E (0.43) | KDM4EAHRNPSR1CYP19A1CYP2D6 | |
| SCHEMBL7241558 | 0.92 | KDM4E (0.43) | KDM4EAHRNPSR1CYP19A1CYP2D6 | |
| SCHEMBL7242964 | 0.90 | TBXAS1 (0.36) | CYP19A1GRM2PTGS2CYP51A1NAMPT | |
| SCHEMBL7242970 | 0.90 | TBXAS1 (0.36) | CYP19A1GRM2PTGS2CYP51A1NAMPT | |
| SCHEMBL7247057 | 0.89 | KDM4E (0.38) | KDM4EAHRNPSR1CYP19A1CYP2C19 | |
| SCHEMBL7247059 | 0.89 | KDM4E (0.38) | KDM4EAHRNPSR1CYP19A1CYP2C19 | |
| SCHEMBL8209474 | 0.85 | MEN1 (0.37) | KDM4ESLC6A4SLC6A3PTGS1CYP2D6 | |
| SCHEMBL8209468 | 0.85 | MEN1 (0.37) | KDM4ESLC6A4SLC6A3PTGS1CYP2D6 | |
| SCHEMBL7703365 | 0.82 | FNTA (0.48) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414145-B1 | TREATING CANCER AND NEUROFIBROMATOSIS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | disclosed |
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |