SCHEMBL8209672

SCHEMBL8209672

O=C1Nc2ccccc2Nc2c(Cl)cccc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 2/20 0.59
NSD2 O96028 1/20 0.59
BCHE P06276 1/20 0.59
DAO P14920 1/20 0.59
ACVR1 Q04771 2/20 0.57
LRRK2 Q5S007 2/20 0.57
PDGFRA P16234 1/20 0.57
FER P16591 1/20 0.57
LTK P29376 1/20 0.57
CDK8 P49336 1/20 0.57
DYRK1B Q9Y463 1/20 0.57
CHEK1 O14757 1/20 0.51
GALR3 O60755 1/20 0.49
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
TGM2 P21980 1/20 0.46
GSK3B P49841 2/20 0.46
CDK5 Q00535 2/20 0.46
PLK4 O00444 1/20 0.46
AURKA O14965 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10935244 0.87 PDGFRA (0.60) CES1NSD2BCHEDAOACVR1
SCHEMBL8508053 0.87 CES1 (0.58) CES1NSD2BCHEDAOACVR1
SCHEMBL25112387 0.86 CES1 (0.77) CES1NSD2BCHEDAOACVR1
SCHEMBL10391668 0.79 CYP1A2 (0.56) CES1NSD2BCHEDAOACVR1
SCHEMBL17065907 0.79 CES1 (0.50) CES1NSD2BCHEDAOACVR1
SCHEMBL5366693 0.78 ACVR1 (0.57) ACVR1LRRK2PDGFRAFERLTK
Hydrochloric Acid SCHEMBL6098100 0.76 ACVR1 (0.55) ACVR1LRRK2PDGFRAFERLTK
SCHEMBL30785263 0.75 AHR (0.50) CES1NSD2BCHEDAOGALR3
SCHEMBL11745225 0.75 CES1 (0.44) CES1NSD2BCHEDAOACVR1
SCHEMBL29417367 0.75 CES1 (1.00) CES1NSD2BCHEDAOMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103715-A COMPOUNDS THAT BIND TO THE DOPAMINE D4 RECEPTOR AND THEIR USE AS ANXIOLYTIC AGENTS, TREATMENT FOR SCHIZOPHRENIA, AND DRUG SCREENING; SIDE EFFECT REDUCTIOON ALLELIX BIOPHARMACEUTICALS INC. (CA) 2000-08-15 US disclosed
US-5968478-A DIBENZOTHIEPINE AS NEUROTRANSMITTERS AND FOR DRUG SCREENING AND TREATMENT OF SCHIZOPHRENIA ALLELIX BIOPHARMACEUTICALS, INC. (CA) 1999-10-19 US disclosed
US-5538965-A TREATMENT OF PSYCHOLOGICAL DISORDERS SUCH AS SCHIZOPHRENIA AND ANXIETY ALLELIX BIOPHARMACEUTICALS INC. (CA) 1996-07-23 US disclosed
WO-1996018622-A1 N-METHYL PIPERAZINE COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY ALLELIX BIOPHARMACEUTICALS INC. (US) 1996-06-20 WO disclosed