Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17881837 | 0.83 | GABRP (0.47) | CES1NSD2BCHEDAOTGM2 | |
| SCHEMBL17882314 | 0.81 | GABRA1 (0.49) | CES1NSD2BCHEDAOTGM2 | |
| SCHEMBL20557580 | 0.79 | ALDH1A1 (0.41) | CES1NSD2BCHEDAOGALR3 | |
| SCHEMBL8209672 | 0.79 | CES1 (0.59) | CES1NSD2BCHEDAOGALR3 | |
| SCHEMBL17065894 | 0.78 | CES1 (0.48) | CES1NSD2BCHEDAOGALR3 | |
| SCHEMBL11875403 | 0.77 | ALDH1A1 (0.43) | CES1NSD2BCHEDAOGALR3 | |
| SCHEMBL10935244 | 0.77 | PDGFRA (0.60) | CES1NSD2BCHEDAOGALR3 | |
| SCHEMBL30776834 | 0.75 | ALDH1A1 (0.42) | MAPTMAOAMAOBPDGFRAFER | |
| SCHEMBL17882327 | 0.74 | HPGD (0.43) | CES1NSD2BCHEDAOMAPT | |
| SCHEMBL17816635 | 0.74 | LRRK2 (0.59) | CES1BCHEMAPTGSK3BCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237387-B1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRCTURES | MERCK PATENT GMBH (DE) | 2023-09-06 | — | — | EP | disclosed |
| EP-3237387-B1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRCTURES | MERCK PATENT GMBH (DE) | 2023-09-06 | — | — | EP | disclosed |
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | MERCK PATENT GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | MERCK PATENT GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-20180331301-A1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-11-15 | — | — | US | disclosed |
| WO-2016102039-A1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRCTURES | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | WO | disclosed |
| WO-2015133808-A1 | ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME | 주식회사 두산 | 2015-09-11 | — | — | WO | disclosed |
| WO-2015133808-A1 | ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME | 주식회사 두산 | 2015-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | DDT, MAOA, MAOB | CES1 2893/4885NSD2 330/4885BCHE 144/4885 |
| US-20180331301-A1 | HETEROCYCLIC COMPOUNDS WITH DIBENZAZAPINE STRUCTURES | DDT, MAOA, MAOB | CES1 2893/4885NSD2 330/4885BCHE 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.