Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | FADS1 | O60427 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16199864 | 0.81 | MAPT (0.43) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL13267376 | 0.80 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL16489240 | 0.79 | KDM4E (0.56) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL18176627 | 0.75 | MEN1 (0.48) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL16489232 | 0.75 | MAPT (0.48) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL14214643 | 0.71 | MAPT (0.67) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL16489241 | 0.71 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL16489227 | 0.71 | GRM4 (0.48) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL28514103 | 0.70 | HDAC3 (0.60) | MAPTNPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL29397593 | 0.70 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |