Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8210331 | 0.81 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL28514103 | 0.66 | HDAC3 (0.60) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL13267376 | 0.65 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL4414699 | 0.64 | MAPT (0.41) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL16489240 | 0.63 | KDM4E (0.56) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL4730873 | 0.62 | MAPT (0.67) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL4730870 | 0.62 | MAPT (0.67) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL27676555 | 0.62 | FADS1 (0.64) | MAPTNPC1RAB9ASMN1; SMN2FADS1 | |
| SCHEMBL4228436 | 0.62 | TSHR (0.43) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL3930649 | 0.62 | MAPT (0.66) | MAPTNPC1RAB9ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190287-B1 | TARTRATE SALTS OR COMPLEXES OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS INC (US) | 2014-10-29 | — | — | EP | disclosed |