Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.48 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202992 | 0.94 | CACNA1B (0.53) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL2795860 | 0.85 | CACNA2D1 (0.67) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL2792070 | 0.84 | CACNA2D1 (0.65) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL8213090 | 0.84 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL2792482 | 0.83 | ALDH1A1 (0.44) | CACNA2D1CACNA1BCACNB1ALDH1A1KDM4E | |
| SCHEMBL2794338 | 0.82 | CACNA2D1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL2796769 | 0.81 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL2796385 | 0.80 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL2793011 | 0.80 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL8211038 | 0.80 | CACNA2D1 (0.47) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168103-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2010-07-01 | — | — | US | disclosed |
| US-20100168103-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2010-07-01 | — | — | US | disclosed |
| WO-2008031227-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168103-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CACNA1C, CACNA1B, ORAI1 | CACNA2D1 22/4885CACNA1B 2/4885CACNB1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.