Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.53 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2794375 | 0.86 | CACNA2D1 (0.73) | CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL2791280 | 0.86 | CACNA2D1 (0.66) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL2794855 | 0.85 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL2796769 | 0.82 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| Hydrochloric Acid SCHEMBL27266176 | 0.81 | CACNA2D1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL9255562 | 0.81 | ATM (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL2796402 | 0.81 | CACNA2D1 (0.60) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL2794772 | 0.81 | CACNA2D1 (0.52) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL2791861 | 0.79 | CACNA2D1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL2791224 | 0.79 | CACNA2D1 (0.58) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168103-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2010-07-01 | — | — | US | disclosed |
| US-20100168103-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2010-07-01 | — | — | US | disclosed |
| WO-2008031227-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168103-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CACNA1C, CACNA1B, ORAI1 | CACNA2D1 22/4885CACNA1B 2/4885CACNB1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.