Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.54 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791280 | 0.84 | CACNA2D1 (0.66) | CACNA2D1CACNA1BCACNB1CACNA1CCYP2D6 | |
| SCHEMBL20804559 | 0.82 | ATM (0.54) | ATMALDH1A1SCN5ASCN9AKMT2A | |
| SCHEMBL20804476 | 0.81 | ATM (0.52) | ATMALDH1A1SCN5ASCN9AKMT2A | |
| SCHEMBL8211709 | 0.81 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1CCYP2D6 | |
| SCHEMBL3398020 | 0.80 | CACNA2D1 (0.56) | ATMCACNA2D1CACNA1BCACNB1CACNA1C | |
| Hydrochloric Acid SCHEMBL27266176 | 0.79 | CACNA2D1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1CCYP2D6 | |
| SCHEMBL1943497 | 0.79 | HRH3 (0.75) | ATMCYP2D6ALDH1A1KMT2AMEN1 | |
| SCHEMBL7501907 | 0.76 | ABL1 (0.54) | ATMKMT2AMEN1 | |
| SCHEMBL26358318 | 0.76 | OPRM1 (0.50) | ATMALDH1A1KMT2AMEN1 | |
| SCHEMBL26358315 | 0.76 | LMNA (0.56) | CYP2D6ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441967-A | Treating cerebral edema; anticholinesterase or brain function-improving agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-15 | — | — | US | disclosed |
| US-5294625-A | 1-benzyl,4-((4-dialkylaminophenyl)carbonyl)piperidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0378207-B1 | CYCLIC AMINE COMPOUNDS AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1993-09-22 | — | — | EP | disclosed |
| US-5177087-A | Cerebral edema, cholinesterase inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0378207-A1 | Cyclic amine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-18 | — | — | EP | disclosed |